Wells Fargo's main office in Cullman will close Sept. 18.
The company announced in September that it would close 800 branches by 2020. The bank closed more than 200 branches in 2017.
Jamee Nelson, a corporate communications official for Wells Fargo, told The Times notices have been sent to local customers about the closing.
"We will continue to operate the South Branch at Town Square, which has Saturday banking," Nelson said.
Nelson said employees at the main branch on 2nd Avenue will be assisted with job searches or they can apply for other openings in the company.
"We make decisions like this based on trends and traffic," Nelson said.
She did not report how many employees are in the main branch in Cullman.
Nelson said the South branch will operate on a schedule of Monday-Thursday, 9 a.m.-4 p.m.; Friday, 9 a.m.- 5 p.m.; and Saturday. 9 a.m.-1 p.m.